Background: Today, the production of plant secondary metabolites has been fastened because of the health value of these products for clinical applications. To date, considerable number of secondary substances have isolated from natural sources through which chemists and biochemists could develop new scaffolds for drug design policies. Unfortunately, the plants only produced a limited quantity of metabolites that might not be enough for isolation and commercial uses. The majority of drug-like metabolites has isolated from wild plants and this issue may threaten the natural diversity of these species within nature. Therefore, finding a promising way to enhance the production of plant metabolites can help researchers for bulky production of these compounds. Over the past decades, various types of bioinoculants have been crafted based on the diversity of soil microorganisms and introduced into global markets for increasing the yield of crop plants.
Result: The growing body of evidence suggests that biofertilizers could improve the growth of medicinal plants vegetative parts which comprised a variety of natural products. The effectiveness of biofertilizers for this issue depends on various factors including the stage of medicinal plant development, soil texture, environmental factors and the power of medicinal plants roots for absorbing nearby nutrients.
Conclusion: Therefore, specification of biofertilizers for the cultivation of medicinal plants should be taken into consideration to increase the yield of medicinal plants for clinical application.